www亚洲午夜人美精片V区,亚洲精品无码AV中文字幕,色婷婷色,性国产VIDEOSGRATIS极品

熱門(mén)搜索: 50072ATAT1, GST-tag Recombinant 40520ATF2, GST-Tag Recombinant 31114GCN5 (727-837), His-tag Recombinant 50074GCN5 (KAT2A), FLAG-tag Recombinant 50071p300 (KAT3B), His-GST-tag Recombinant 11004ACHE, His-Tag Recombinant 50272BCL-2, His-Tag Recombinant 100077BCL2A1, His-Tag Recombinant 100080BCL2L10, His-Tag Recombinant 100091BCL2L2, His-Tag Recombinant 80113Caspase6, His-tag Recombinant 70000Caspase7, His-tag Recombinant 80114Caspase8, His-tag Recombinant 100543GPX4, FLAG-Tag Recombinant 100054MALT1, FLAG-Tag (Mouse) Recombinant 100637MCL-1 His-Tag (Mouse) Recombinant

產(chǎn)品展示/ Product display

您的位置:首頁(yè)  /  產(chǎn)品展示  /    /  PDE Assay Kits  /  79573PDE4B (Dog) Assay Kit

PDE4B (Dog) Assay Kit

●Purchase●DescriptionPhosphodiesterases(PDEs)playanimportantroleindynamicregulationofcAMPandcGMPsignaling

  • 產(chǎn)品型號(hào):79573
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時(shí)間:2023-11-11
  • 訪  問(wèn)  量:189
立即咨詢(xún)

聯(lián)系電話(huà):

詳細(xì)介紹
Purchase
Description

Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE4 selective inhibitors are currently in clinical trials for the treatment of diseases related to inflammatory disorders. Altered activity of PDE4B has been associated with schizophrenia and bipolar disorder. It has also recently been found to modulate cognition, as reduction in PDE4B activity improves memory and long-term plasticity in mouse models.

The dog PDE4B (dPDE4B) Assay Kit is designed for identification of inhibitors of dog PDE4b using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by canine PDE4B to the binding agent.

Phosphodiesterases catalyze the hydrolysis of the phosphodiester bond in dye-labeled cyclic monophosphates. Beads selectively bind the phosphate group in the nucleotide product. This increases the size of the nucleotide relative to unreacted cyclic monophosphate. In the polarization assay, dye molecules with absorption transition vectors parallel to the linearly-polarized excitation light are selectively excited. Dyes attached to the rapidly-rotating cyclic monophosphates will obtain random orientations and emit light with low polarization. Dyes attached to the slowly-rotating nucleotide-bead complexes will not have time to reorient and therefore will emit highly polarized light.

The Dog PDE4B Assay Kit comes in a convenient 96-well format, with purified dPDE4B enzyme, fluorescently labeled dPDE4B substrate (cAMP), binding agent, and PDE assay buffer for 100 enzyme reactions. The key to the Dog PDE4B Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for dPDE4B reactions. First, the fluorescently labeled cAMP is incubated with a sample containing dPDE4B for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader equipped for the measurement of fluorescence polarization.

留言詢(xún)價(jià)

留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話(huà):

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說(shuō)明:

  • 驗(yàn)證碼:

    請(qǐng)輸入計(jì)算結(jié)果(填寫(xiě)阿拉伯?dāng)?shù)字),如:三加四=7
關(guān)注公眾號(hào)

郵箱:infocn@bpsbioscience.com

傳真:

地址:上海靜安區(qū)

Copyright © 2025 BPS Bioscience Inc.版權(quán)所有   備案號(hào):   技術(shù)支持:化工儀器網(wǎng)

TEL:

掃碼加微信