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IL-15 Responsive Luciferase Reporter Cell Line

  • 產品型號:
  • 廠商性質:生產廠家
  • 更新時間:2023-10-12
  • 訪  問  量:142
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詳細介紹
  • 數量:

    1

  • 供應商:

    BPS Bioscience

  • 細胞類型:

    穩(wěn)轉細胞系

  • 品系:

    Jurkat

  • 組織來源:

    /

  • 相關疾?。?/span>

    多種

  • 物種來源:

    human

  • 免疫類型:

    多種

  • 器官來源:

  • 運輸方式:

    干冰

  • 年限:

    10

  • 生長狀態(tài):

    良好

  • CAS號:

  • 英文名:

    IL-15 Responsive Luciferase Reporter Cell Line

  • 注冊證號:

    /

  • 規(guī)格:

    2管

This recombinant Jurkat cell line is a biologically relevant system to measure activation of the IL-15 cytokine receptor by IL-15. The cells were engineered for constitutive expression of human CD122 (IL-15Rβ; IL-2Rβ; NM_000878.4), and conditional expression of firefly luciferase driven by STAT5 response elements located upstream of the minimal TATA promoter. Expression of CD122 allows formation of a functional IL-15 receptor at the surface of Jurkat cells, which naturally express high levels of CD132 (also known as IL-15 receptor subunit γc). Activation of the STAT5 signaling pathway in response to IL-15 or IL-15 analogs can be monitored by measuring luciferase activity.

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